The advantages of modular over traditional construction for pharmaceutical...
ISO standard 14644-1 defines a cleanroom as "a room in which the concentration of airborne particles is controlled, and which is constructed and used in a manner to minimise the introduction, generation, and retention of particles inside the room and...
Difference between positive and negative pressure containment systems
Isolators are an arrangement of physical barriers that use containment as a strategy to create an enclosed working space detached from the surrounding environment. Isolators enable manipulation of the processes within the enclosed space from the outside without compromising integrity....
Any challenge can be overcome with clarity, focus and a committed team
A little over a year ago, a potential customer based in Maghreb reached out to us. They wanted an R&D scale manufacturing system for an OEB 5 oncological product. We sat down with them to understand their needs and probed...
Key differences between static and dynamic pass boxes
In a pharmaceutical manufacturing facility where a sterile environment is paramount, equal importance must be given to ensuring the movement of materials does not compromise the sanctity of the cleanroom. Operators account for the largest single source of contamination in...
Common cleanroom hazards you should know about
While cleanrooms are supposed to be the quintessential sterile space, there is no guarantee of a perfect, contaminant free cleanroom. However risk of contamination can be minimised by adhering to proper protocols including room pressure requirements, proper gowning procedures. While...
The benefits of intertwined circuiting in split coils
In my earlier post on Treated Fresh Air technology, I spoke about how the HVAC sector is continually evolving as new technologies develop and new concepts come into play. As most of these technologies and innovations are relatively unknown, we...
The increasingly important role of RABS in aseptic filling operations
There are multiple potential sources of contamination in any cleanroom environment, from the transfer of materials to the incoming air system. Even in a well-designed and operated cleanroom set up, operators present one of the primary sources of incoming contamination....
New developments in Treated Fresh Air technology
With climate change no longer a myth but a catastrophic reality, it has become vital for every manufacturing company across the globe to implement sustainable engineering in design and manufacturing. Sustainable engineering is the process of designing or operating systems...